Tartu Ülikooli arstiteaduskonnas pakume kahte valikainet:

  • Sissejuhatus androloogiasse – kokku 20 loengutundi
  • Androloogiline uroloogia – kokku 20 tundi seminare ja loenguid

 

Käigusolevad olulisemad teadusuuringud

  • Meeste viljatuse põhjused - epidemioloogiline uuring meeste viljatuse põhjuste kohta Eestis.
  • Ülekaalu ja metaboolse sündroomi mõju meeste viljakusele ja üldtervisele
  • Mitteinvasiivsete biomarkerite väljatöötamine viljatuse diagnostikaks ja raseduse jälgimiseks. Koostööprojekt Tartu Ülikooli moleulaar- ja rakubioloogia instituudi inimese molekulaargeneetika uurimisgrupi (uurimisgteema juht prof. Maris Laan), Tartu Ülikooli Kliinikumi naistekliiniku, Tartu Ülikooli Kliinikumi androloogiakeskuse ja Quattromed HTI Laborid OÜ vahel
  • Euroopa meeste vananemise uuring. Koostööprojekt 8 Euroopa ülikooli androloogiakeskuste vahel. Uurimisteema juht Prof. Fred Wu, Manchesteri Ülikoolist. Koduleht: http://www.emas.man.ac.uk/Main.asp

 

Olulisemad publikatsioonid vastavalt androloogia põhiteemadele:

1. Meeste reproduktiivne funktsioon ja viljatus

Ehala-Aleksejev K, Punab M. The effect of metabolic syndrome on male reproductive health: A cross-sectional study in a group of fertile men and male partners of infertile couples. PLoS One. 2018 Mar 16;13(3):e0194395.

Punab M, Poolamets O, Paju P, Vihljajev V, Pomm K, Ladva R, Korrovits P, Laan M. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod. 2017 Jan;32(1):18-31.

Erenpreiss J, Punab M, Zilaitiene B, Hlevicka S, Zayakin P, Matulevicius V, Tomas Preiksa R, Jørgensen N. Semen quality of young men from the general population in Baltic countries. Hum Reprod. 2017 Jun 1;32(6):1334-1340.

Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. 2016 Dec;70(6):1019-1029

Jørgensen N, Joensen UN, Toppari J, Punab M, Erenpreiss J, Zilaitiene B, Paasch U, Salzbrunn A, Fernandez MF, Virtanen HE, Matulevicius V, Olea N, Jensen TK, Petersen JH, Skakkebæk NE, Andersson AM. Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men. Hum Reprod. 2016 May;31(5):947-57.

Ehala-Aleksejev K, Punab M. Serum hepatic enzyme activity in relation to semen quality and serum reproductive hormone levels among Estonian fertile Men. Andrology. 2016 Jan;4(1):152-9

Ehala-Aleksejev K, Punab M. The different surrogate measures of adiposity in relation to semen quality and serum reproductive hormone levels among Estonian fertile men. Andrology. 2015 Mar;3(2):225-34.

Jensen TK, Swan S, Jørgensen N, Toppari J, Redmon B, Punab M, Drobnis EZ, Haugen TB, Zilaitiene B, Sparks AE, Irvine DS, Wang C, Jouannet P, Brazil C, Paasch U, Salzbrunn A, Skakkebæk NE, Andersson AM. Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA. Hum Reprod. 2014 Aug;29(8):1801-9.

Grigorova M, Punab M, Punab AM, Poolamets O, Vihljajev V, Zilaitienė B, Erenpreiss J, Matulevičius V, Laan M. Reproductive physiology in young men is cumulatively affected by FSH-action modulating genetic variants: FSHR -29G/A and c.2039 A/G, FSHB -211G/T. PLoS One. 2014 Apr 9;9(4):e94244.

Ausmees K, Korrovits P, Timberg G, Erm T, Punab M, Mändar R. Semen quality in middle-aged males: associations with prostate-specific antigen and age-related prostate conditions. Hum Fertil (Camb). 2014 Mar;17(1):60-6

Türk S, Mändar R, Mahlapuu R, Viitak A, Punab M, Kullisaar T. Male infertility: decreased levels of selenium, zinc and antioxidants. J Trace Elem Med Biol. 2014 Apr;28(2):179-85

Punab M, Kullisaar T, Mändar R. Male infertility workup needs additional testing of expressed prostatic secretion and/or post-massage urine. PLoS One. 2013 Dec 9;8(12):e82776

Ausmees K, Korrovits P, Timberg G, Punab M, Mändar R. Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction. Int Braz J Urol. 2013 Sep-Oct;39(5):727-40

Kullisaar T, Türk S, Kilk K, Ausmees K, Punab M, Mändar R. Increased levels of hydrogen peroxide and nitric oxide in male partners of infertile couples. Andrology. 2013 Nov;1(6):850-8

Grigorova M, Punab M, Poolamets O, Sõber S, Vihljajev V, Žilaitienė B, Erenpreiss J, Matulevičius V, Tsarev I, Laan M.Study in 1790 Baltic men: FSHR Asn680Ser polymorphism affects total testes volume. Andrology. 2013 Mar;1(2):293-300

Mändar R, Kullisaar T, Borovkova N, Punab M. Sexual intercourse with leukocytospermic men may be a possible booster of oxidative stress in female partners of infertile couples. Andrology. 2013 May;1(3):464-8

Ausmees K, Mändar R, Korrovits P, Zarkovski M, Timberg G, Punab M. Reproductive function in middle-aged males: healthy men versus male partners of infertile couples. Andrologia. 2014 Mar;46(2):118-25

Grigorova, M.; Punab, M.; ?ilaitien?, B.; Erenpreiss, J.; Ausmees, K.; Matulevi?ius, V.; Tsarev, I.; Jørgensen, N.; Laan, M. (2011). Genetically Determined Dosage of Follicle-Stimulating Hormone (FSH) Affects Male Reproductive Parameters. Journal of Clinical Endocrinology and Metabolism, 96(9), E1534 - E1541.

Borovkova, Natalja; Korrovits, Paul; Ausmees, Kristo; Türk, Silver; Jõers, Kai; Punab, Margus; Mändar, Reet. (2011). Influence of sexual intercourse on genital tract microbiota in infertile couples. Anaerobe, 17, 414 - 418.

Grigorova, M.; Punab, M.; Poolamets, O.; Kelgo, P.; Ausmees, K.; Korrovits, Paul; Vihljajev, V.; Laan, M. (2010). Increased prevalence of the – 211 T allele of follicle stimulating hormone (FSH) beta subunit promoter polymorphism and lower serum FSH in infertile men. Journal of Clinical Endocrinology and Metabolism, 95(1), 100 - 108.

Kullisaar, T.; Türk, S.; Punab, M.; Korrovits, P.; Kisand, K.; Rehema, A.; Zilmer, K.; Zilmer, M.; Mändar, R. (2008). Oxidative stress in leukocytospermic prostatitis patients: preliminary results. Andrologia, 40(3), 161 - 172.

Punab, M. (2007). Male fertility and its risk factors in Estonia .Tartu University Press

Punab, M.; Zilaitiene, B.; Jorgensen, N.; Horte, A.; Matulevicius, V.; Peetsalu, A.; Skakkebaek, NE. (2002). Regional differences in semen qualities in the Baltic region. International Journal of Andrology, 25(4), 243 - 252.

2. Eesnäärmehaigused ja prostatiit

Korrovits P, Poolamets O, Mändar R, Punab M. Inflammatory reaction found in prostate-specific material - method standardization and proposed optimal cut-off points. Andrology. 2017 Sep;5(5):958-963.

Mändar R, Punab M, Korrovits P, Türk S, Ausmees K, Lapp E, Preem JK, Oopkaup K, Salumets A, Truu J. Seminal microbiome in men with and without prostatitis. Int J Urol. 2017 Mar;24(3):211-216

Bentmar Holgersson M, Giwercman A; EMAS group, Bjartell A, Wu FC, Huhtaniemi IT, O'Neill TW, Pendleton N, Vanderschueren D, Lean ME, Han TS, Finn JD, Kula K, Forti G, Casanueva FF, Bartfai G, Punab M; EMAS group, Lundberg Giwercman Y. Androgen receptor polymorphism-dependent variation in prostate-specific antigen concentrations of European men. Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):2048-56

Aavik T, Aavik A, Punab M. Personal values that support and counteract utilization of a screening test for prostate cancer. Behav Med. 2014;40(1):22-8

Kullisaar, T.; Türk, S.; Punab, M.; Mändar, R. (2012). Oxidative stress--cause or consequence of male genital tract disorders? The Prostate, 72(9), 799 - 783.

Korrovits, Paul; Punab, Margus; Mändar, Reet (2011). Asymptomatic inflammatory prostatitis. Charleston, USA: CreateSpace

Korrovits, Paul; Ausmees, Kristo; Mändar, Reet; Punab, Margus (2011). Seminal interleukin-6 and serum prostate-specific antigen as possible predictive biomarkers in asymptomatic inflammatory prostatitis. Urology, 78(2), 442 - 446.

Türk, Silver; Punab, Margus; Mändar, Reet (2009). Antimicrobial Susceptibility Patterns of Coryneform Bacteria Isolated from Semen. . The Open Infectious Diseases Journal, 3, 31 - 36.

Korrovits, P.; Ausmees, K.; Mändar, R.; Punab, M. (2008). Prevalence of asymptomatic inflammatory (National Institutes of Health Category IV) prostatitis in young men according to semen analysis. Urology, 71(6), 1010 - 1015.

Punab, M.; Loivukene, K.; Kermes, K.; Mandar, R. (2003). The limit of leucocytospermia from the microbiological viewpoint. Andrologia, 35(5), 271 - 278.

3. Meeste hüpogonadism, andropaus ja vananemine

Grigorova M, Punab M, Poolamets O, Adler M, Vihljajev V, Laan M. Genetics of Sex Hormone-Binding Globulin and Testosterone Levels in Fertile and Infertile Men of Reproductive Age. J Endocr Soc. 2017 Apr 11;1(6):560-576

Ahern T, Swiecicka A, Eendebak RJ, Carter EL, Finn JD, Pye SR, O'Neill TW, Antonio L, Keevil B, Bartfai G, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Rastrelli G, Rutter MK, Vanderschueren D, Huhtaniemi IT, Wu FC; EMAS study group. Natural history, risk factors and clinical features of primary hypogonadism in ageing men: Longitudinal Data from the European Male Ageing Study. Clin Endocrinol (Oxf). 2016 Dec;85(6):891-901

Antonio L, Wu FC, O'Neill TW, Pye SR, Ahern TB, Laurent MR, Huhtaniemi IT, Lean ME, Keevil BG, Rastrelli G, Forti G, Bartfai G, Casanueva FF, Kula K, Punab M, Giwercman A, Claessens F, Decallonne B, Vanderschueren D; European Male Ageing Study Study Group. Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone. J Clin Endocrinol Metab. 2016 Jul;101(7):2647-57

Rastrelli G, Carter EL, Ahern T, Finn JD, Antonio L, O'Neill TW, Bartfai G, Casanueva FF, Forti G, Keevil B, Maggi M, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Vanderschueren D, Wu FC; EMAS Study Group. Development of and Recovery from Secondary Hypogonadism in Aging Men: Prospective Results from the EMAS. J Clin Endocrinol Metab. 2015 Aug;100(8):3172-82.

Pye SR, Huhtaniemi IT, Finn JD, Lee DM, O'Neill TW, Tajar A, Bartfai G, Boonen S, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Rutter MK, Vanderschueren D, Wu FC; EMAS Study Group. Late-onset hypogonadism and mortality in aging men. J Clin Endocrinol Metab. 2014 Apr;99(4):1357-66

Wu, Frederick C. W.; Tajar, Abdelouahid; Beynon, Jennifer M.; Pye, Stephen R.; Silman, Alan J.; Finn, Joseph D.; O'Neill, Terence W.; Bartfai, Gyorgy; Casanueva, Felipe F.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Kula, Krzysztof; Lean, Michael E. J.; Pendleton, Neil; Punab, Margus; Boonen, Steven; Vanderschueren, Dirk; Labrie, Fernand; Huhtaniemi, Ilpo T.; Grp, Emas (2010). Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men. New England Journal of Medicine, 363, 123-135

Lee, D. M.; Tajar, A.; Pye, S. R.; Boonen, S.; Vanderschueren, D.; Bouillon, R.; O'Neill, T. W.; Bartfai, G.; Casanueva, F. F.; Finn, J. D.; Forti, G.; Giwercman, A.; Han, T. S.; Huhtaniemi, I. T.; Kula, K.; Lean, M. E. J.; Pendleton, N.; Punab, M.; Wu, F. C. W.; Grp, Emas Study (2012). Association of hypogonadism with vitamin D status: the European Male Ageing Study (European Journal of Endocrinology). European Journal of Endocrinology, 166, 77 - 85.

Tajar, A.; Huhtaniemi, I. T.; O'Neill, T. W.; Finn, J. D.; Pye, S. R.; Lee, D. M.; Bartfai, G.; Boonen, S.; Casanueva, F. F.; Forti, G.; Giwercman, A.; Han, T. S.; Kula, K.; Labrie, F.; Lean, M. E.; Pendleton, N.; Punab, M.; Vanderschueren, D.; Wu, F. C.; Group, EMAS (2012). Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS). Journal of Clinical Endocrinology and Metabolism, 97, 1508 - 1516.

Tajar, Abdelouahid; Forti, Gianni; O'Neill, Terence W.; Lee, David M.; Silman, Alan J.; Finn, Joseph D.; Bartfai, Gyoergy; Boonen, Steven; Casanueva, Felipe F.; Giwercman, Aleksander; Han, Thang S.; Kula, Krzysztof; Labrie, Fernand; Lean, Michael E. J.; Pendleton, Neil; Punab, Margus; Vanderschueren, Dirk; Huhtaniemi, Ilpo T.; Wu, Frederick C. W.; Grp, Emas (2010). Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study. Journal of Clinical Endocrinology & Metabolism, 95, 1810-1818

Lee, David M.; Tajar, Abdelouahid; Ulubaev, Aslan; Pendleton, Neil; O'Neill, Terence W.; O'Connor, Daryl B.; Bartfai, Gyorgy; Boonen, Steven; Bouillon, Roger; Casanueva, Felipe F.; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Lean, Michael E. J.; Punab, Margus; Silman, Alan J.; Vanderschueren, Dirk; Wu, Frederick C. W.; Grp, Emas Study (2009). Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. Journal of Neurology Neurosurgery and Psychiatry, 80, 722 - 729.

4. Seksuaalhäired

Corona G., Wu FC, Forti G., Casanueva F.F., Finn J.D., Giwercman A., Punab M., et al (2012). Thyroid hormones and male sexual function. International Journal of Andrology, 668 - 679.

Han, Thang S.; Tajar, Abdelouahid; O'Neill, Terence W.; Jiang, Min; Bartfai, Gyoergy; Boonen, Steven; Casanueva, Felipe; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Pendleton, Neil; Punab, Margus; Silman, Alan J.; Vanderschueren, Dirk; Lean, Michael E. J.; Wu, Frederick C. W.; Grp, Emas (2011). Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study. European Journal of Endocrinology, 164, 1003-1011

O'Connor, Daryl B.; Lee, David M.; Corona, Giovanni; Forti, Gianni; Tajar, Abdelouahid; O'Neill, Terence W.; Pendleton, Neil; Bartfai, Gyorgy; Boonen, Steven; Casanueva, Felipe F.; Finn, Joseph D.; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Labrie, Fernand; Lean, Michael E. J.; Punab, Margus; Silman, Alan J.; Vanderschueren, Dirk; Wu, Frederick C. W.; European Male Ageing Study, Grp (2011). The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men. Journal of Clinical Endocrinology & Metabolism, 96, E1577-E1587

5. Sugutrakti mikrobioota ja põletikud

Mändar R, Türk S, Korrovits P, Ausmees K, Punab M. Impact of sexual debut on culturable human seminal microbiota. Andrology. 2018 Mar 7.

Tjagur S, Mändar R, Punab M. Prevalence of Mycoplasma genitalium and other sexually transmitted infections causing urethritis among high-risk heterosexual male patients in Estonia. Infect Dis (Lund). 2018 Feb;50(2):133-139.

Mändar R, Punab M, Borovkova N, Lapp E, Kiiker R, Korrovits P, Metspalu A, Krjutškov K, Nõlvak H, Preem JK, Oopkaup K, Salumets A, Truu J. Complementary seminovaginal microbiome in couples. Res Microbiol. 2015 Jun;166(5):440-447

6. Meeste üldtervis

Overman MJ, Pendleton N, O'Neill TW, Bartfai G, Casanueva FF, Forti G, Rastrelli G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean MEJ, Punab M, Lee DM, Correa ES, Ahern T, Laurent MR, Verschueren SMP, Antonio L, Gielen E, Rutter MK, Vanderschueren D, Wu FCW, Tournoy J; EMAS study group. Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study. Am J Geriatr Psychiatry. 2017 Jun;25(6):662-671.

Han TS, Correa E, Lean ME, Lee DM, O'Neill TW, Bartfai G, Forti G, Giwercman A, Kula K, Pendleton N, Punab M, Rutter MK, Vanderschueren D, Huhtaniemi IT, Wu FC, Casanueva FF; and the EMAS Study Group. Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS). Endocrine. 2017 Feb;55(2):456-469

Overman MJ, Pendleton N, O'Neill TW, Bartfai G, Casanueva FF, Finn JD, Forti G, Rastrelli G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean MEJ, Punab M, Lee DM, Correa ES, Ahern T, Verschueren SMP, Antonio L, Gielen E, Rutter MK, Vanderschueren D, Wu FCW, Tournoy J; EMAS Study Group. Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study. Eur J Nutr. 2017 Sep;56(6):2093-2103.

McCabe PS, Pye SR, Beth JM, Lee DM, Tajar A, Bartfai G, Boonen S, Bouillon R, Casanueva F, Finn JD, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Pendleton N, Punab M, Vanderschueren D, Wu FC, O'Neill TW; EMAS Study Group. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study. BMC Musculoskelet Disord. 2016 Jan 16;17:32

Wade KF, Lee DM, McBeth J, Ravindrarajah R, Gielen E, Pye SR, Vanderschueren D, Pendleton N, Finn JD, Bartfai G, Casanueva FF, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Wu FC, O'Neill TW. Chronic widespread pain is associated with worsening frailty in European men. Age Ageing. 2016 Mar;45(2):268-74.

NCD Risk Factor Collaboration (NCD-RisC). Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331,288 participants. Lancet Diabetes Endocrinol. 2015 Aug;3(8):624-37.

Antonio L, Wu FC, O'Neill TW, Pye SR, Carter EL, Finn JD, Rutter MK, Laurent MR, Huhtaniemi IT, Han TS, Lean ME, Keevil BG, Pendleton N, Rastrelli G, Forti G, Bartfai G, Casanueva FF, Kula K, Punab M, Giwercman A, Claessens F, Decallonne B, Vanderschueren D; EMAS Study Group. Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men. J Clin Endocrinol Metab. 2015 Apr;100(4):1396-404.

Han TS, Lee DM, Lean ME, Finn JD, O'Neill TW, Bartfai G, Forti G, Giwercman A, Kula K, Pendleton N, Punab M, Rutter MK, Vanderschueren D, Huhtaniemi IT, Wu FC, Casanueva FF; EMAS Study Group. Associations of obesity with socioeconomic and lifestyle factors in middle-aged and elderly men: European Male Aging Study (EMAS). Eur J Endocrinol. 2015 Jan;172(1):59-67

 

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